ArticleMaterials today. Bio2026
Immunomodulatory and dentinogenic potential of surface-engineered hesperetin-functionalized composite scaffolds for pulp-dentin regeneration.
Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- More than a trend: the rationale for using bioactive materials in clinical practice.Brazilian oral research · 2026Review
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Maintaining dental pulp vitality and promoting dentin regeneration in inflamed environments requires biomaterials that not only support cell differentiation but also actively regulate immune signaling. Here, we present a bioinstructive, immunomodulatory nanofibrous platform composed of polycaprolactone and nano-hydroxyapatite (PCL/nHA), surface-engineered through alkaline hydrolysis (H-) to enhance hydrophilicity and loaded with the flavonoid hesperetin (+HT) for sustained bioactive release. Physicochemical analyses confirmed improved surface wettability, calcium ion release, and diffusion-driven hesperetin delivery, all without compromising the scaffold's structure. In vitro, the scaffolds facilitated the migration, proliferation, and odontogenic differentiation of human dental pulp cells, leading to a significant increase in mineralized matrix formation. Using lipopolysaccharide-stimulated macrophages and a 3D inflammatory pulp capping model, the scaffolds modulated immune responses by downregulating pro-inflammatory cytokines and upregulating pro-resolving mediators, while also promoting dentinogenic and angiogenic gene expression. In vivo, subcutaneous implantation demonstrated favorable host integration, reduced inflammatory infiltration, early M2-skewed macrophage polarization, and organized extracellular matrix formation. Overall, this study introduces a surface-engineered, flavonoid-releasing scaffold as a bioinstructive platform that combines immunomodulation and odontoblastic signaling, providing mechanistic insight for designing next-generation materials aimed at regenerating the dentin-pulp interface under inflammatory conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.