ReviewMaterials today. Bio2026
Click chemistry-based drug delivery systems for targeted cancer therapy.
Review in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Drug delivery systems (DDSs) play a crucial role in improving the efficacy and reducing the side effects of cancer treatment. However, traditional DDSs face challenges such as poor targeting, tissue penetration, and uncontrolled drug release. Click chemistry offers a powerful tool for addressing these limitations by enabling precise modification and targeting of DDSs. This review explores the application of click chemistry in the construction of active targeted DDSs for cancer therapy, focusing on two key strategies: in vitro and in vivo. In vitro strategies involve direct coupling of targeting agents to carrier materials, while in vivo strategies utilize metabolic engineering and click chemistry for cell labeling and drug delivery. The review discusses the advantages and limitations of different click chemistry reactions, including copper-catalyzed azide-alkyne cycloaddition (CuAAC), strain-promoted azide-alkyne cycloaddition (SPAAC), inverse electron-demand Diels-Alder (IEDDA) reaction, thiol-ene reaction, sulfur (VI) fluoride exchange (SuFEx) reaction, and selenium-nitrogen exchange (SeNEx) reaction. It also highlights recent advancements in using click chemistry to construct multifunctional DDSs, such as tumor-targeted biomimetic systems and cell-based delivery systems. Finally, the review outlines the challenges and future directions of click chemistry in drug delivery, emphasizing the need for precise control, expanded toolkits, and integration with emerging technologies to create intelligent, multifunctional DDSs with enhanced therapeutic efficacy and reduced side effects.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.