Evidence map›Paper›PMID 41769305›Full record

ArticleAnnual Modeling and Simulation Conference (ANNSIM). Annual Modeling and Simulation Conference (Online)2025

COMPUTATIONAL ANALYSIS OF THE NOVEL LQT3 MUTATIONS G1481V AND Q1491H IN MYOCARDIAL AND PURKINJE CELLS.

Anthony Owusu-Mensah, Omer Berenfeld, Quentin Plumereau, Mohamed Chahine, Michel Audette

Abstract read
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In one paragraph

Article in Annual Modeling and Simulation Conference (ANNSIM). Annual Modeling and Simulation Conference (Online), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Anthony Owusu-MensahElectrical and Computer Engineering, Old Dominion University, United States of America.
Omer BerenfeldCenter for Arrhythmia Research, Internal Medicine, University of Michigan, United States of America.
Quentin PlumereauCERVO Brain Research Center, Quebec City, Canada.
Mohamed ChahineCERVO Brain Research Center, Quebec City, Canada.
Michel AudetteElectrical and Computer Engineering, Old Dominion University, United States of America.

Funding

Electrical Activity Patterns in Onset and Cessation of Atrial FibrillationR01HL156961 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BERENFELD, OMER · 2022 to 2025
$2.4M
Mapping Electrical Activation in Atrial FibrillationR01HL118304 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BERENFELD, OMER · 2013 to 2016
$1.5M
Extracorporeal and Endoscopic SWIR Mapping of Dynamic Muscle FunctionR21EB032661 · NIBIB · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ANUMONWO, JUSTUS M, BERENFELD, OMER · 2022 to 2023
$401k
Hyperspectral Mapping of Cardiac Excitation and Contraction DynamicsR21HL153694 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ANUMONWO, JUSTUS M, BERENFELD, OMER · 2020 to 2021
$401k
NHLBI NIH HHS R01 HL118304NHLBI NIH HHS R01 HL156961NHLBI NIH HHS R21 HL153694NIBIB NIH HHS R21 EB032661
6 · The paper itself

Abstract

Long QT Syndrome type 3 (LQT3) arises from mutations in SCNA5 gene encoding the Nav1.5 sodium channel. We studied two novel mutations (G1481V and Q1491H) found in infants who suffered sudden cardiac death. Using computational modeling, we incorporated experimental data into a Na

Indexed as

Delayed afterdepolarizationEarly afterdepolarizationLong QT SyndromePurkinje cells

Identifiers

PMID41769305
PMCPMC12948445

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.