ArticleJournal of general and family medicine2026
Survival Time Difference Between High and Low Symptom Burden Considering Physical and Emotional Symptoms Among Terminal Cancer Patients.
Article in Journal of general and family medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07698782 (Advanced Cancer Stage and Healthcare Coverage Predict Longitudinal Psychological Distress and Clinical Outcomes in Patients Undergoing Radiotherapy), which is not on this map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Advanced Cancer Stage and Healthcare Coverage Predict Longitudinal Psychological Distress and Clinical Outcomes in Patients Undergoing Radiotherapy
Who cites it
1 citing paper in PubMed.
- Beyond the Acknowledged Limitations: Critical Methodological Gaps in Prognostic Assessment of Symptom Burden Among Terminal Cancer Patients.Journal of general and family medicine · 2026Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Although symptom assessment is fundamental to palliative care, its independent impact on survival remains unclear. This study addresses survival time differences between high and low symptom burden, assessed using the Edmonton Symptom Assessment System (ESAS), among terminal cancer patients (PPS ≤ 30) at Naresuan University Hospital. Material and Methods: A bidirectional observational cohort study was conducted from October 1, 2019, to January 31, 2024. Patients were categorized into high or low symptom distress groups based on ESAS physical, emotional, and total symptom scores. Multivariable models adjusted for age, sex, BMI, Charlson Comorbidity Index, and metastatic sites. Survival impact was quantified using restricted mean survival time (RMST) and hazard ratios (HR). Results: A total of 143 terminal cancer patients were included; 76 were males (53.15%) and the average age was 66.17 ± 12.11 years. HRs for high physical, emotional, and total symptom distress scores (TSDS) were 1.50 (95% CI: 1.02-2.20), 1.02 (95% CI: 0.64-1.63), and 1.34 (95% CI: 0.91-1.97), respectively. Only the physical domain remained significant after adjustment. RMST demonstrated that patients with high physical burden experienced a significant survival reduction of 3.70 days (95% CI: -7.17 to -0.23) within a 28-day follow-up period. Conclusions: High physical symptom burden is significantly associated with shorter survival in terminal cancer patients. These findings highlight the prognostic importance of physical symptoms, emphasizing the need for effective symptom management to optimize remaining survival time.
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