ArticleArchives of Razi Institute2025
Research on the Synergistic Effect of A Novel Apoptosis Inducer Combined with AKT and HSP90 Selective Inhibitors on Hormone-Sensitive and Hormone-Resistant Breast Cancer Cell Lines.
Article in Archives of Razi Institute, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
One of the frequent malignant tumors affecting women is breast cancer. This tumor develops and occurs due to several internal and external factors. Resistance remains a key challenge in modern breast cancer therapy. Novel 1-substituted isatin-5-sulfonamides with antiproliferative effects based on isatin-core-containing antitumor compounds were synthesized in three stages via alkylation using benzyl chlorides. The study focuses on the synergistic effect of the obtained 1-substituted isatin-5-sulfonamides, exhibiting pro-apoptotic activity and is combined with heat shock protein 90 (HSP90) and protein kinase B (AKT) selective inhibitors in breast cancer cell lines, which are sensitive and resistant to antiestrogens.To create resistance, 4-hydroxytamoxifen (HT) was applied to create a resistant cell subline (MCF7/HT), achieving a resistance index of 2. MCF7/p53-LUC cell subline was obtained through transfection using the p53-responsive luciferase reporter plasmid. The lead compound
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