Evidence map›Paper›PMID 41769222›Full record

ReviewEJHaem2026

A Review of CEBPA's Role in Hereditary Leukemia.

Tara Rakiewicz, Neil Palmisiano

Abstract readReview
In one paragraph

Review in EJHaem, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Tara RakiewiczSidney Kimmel Comprehensive Cancer Center Thomas Jefferson University Philadelphia Pennsylvania USA.ORCID https://orcid.org/0009-0001-8332-6326
Neil PalmisianoRobert Wood Johnson Barnabas Health Rutgers Cancer Institute New Brunswick New Jersey USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Advances in genetic testing have allowed for extensive testing and identification of previously unrecognized inherited conditions; a prominent area of this research includes familial patterns of acute myeloid leukemia (AML). Recognition of familial related hematologic malignancies can have lasting implications for both patients and their treatment plans, as well as their families. Aims: This review summarizes the specific familial AML disease, CCAAT/enhancer binding protein-alpha (CEBPA) associated AML. Content: We highlight CEBPA's function, pathogenesis, and potential treatment considerations after identification of the pathogenic or likely pathogenic (P/LP) germline mutations in cases of AML. Discussion of testing and screening for affected family members is also reviewed. Summary: Identification of CEBPA familial AML is necessary for appropriate treatment planning and has additional implications for familial testing and screening. Clinical practice is still evolving treatment paradigms for these patients and their families.

Indexed as

acute myeloid leukemiaCEBPAfamilialgermline mutations

Identifiers

PMID41769222
PMCPMC12948715

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.