ArticleMacromolecules2025
Fabrication and Characterization of Tetra-PEG-Derived Hydrogels of Controlled Softness.
Article in Macromolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
4 authors.
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Abstract
Tetra-PEG hydrogels are known for their exceptionally homogeneous network structure and high mechanical stability. In this study, we demonstrate how the tetra-PEG framework can be adapted to create hydrogels of widely variable softness, with elastic moduli as low as 1-10 Pa. This is achieved by systematically tuning the ratio of tetra-functional and linear PEG macromers, producing networks with long, linear polymer segments that are intermittently cross-linked. The resulting hydrogels may serve as simple model systems for more complex biological hydrogels. Using small-angle neutron scattering (SANS), dynamic light scattering (DLS), rheometry, and microrheology, we reveal how the ratio of linear and tetra-functional precursor macromers influences the network structure and mechanical properties. These hydrogels, with precisely controllable rheological and structural characteristics, offer a versatile platform for studying the structure-property relationship in hydrogels mimicking the properties of biological systems such as mucus. The introduced principles are general and provide a foundation for designing new hydrogel materials with tailored properties for biomedical applications.
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