Evidence map›Paper›PMID 41769202›Full record

Reviewnpj biomedical innovations2026

Nucleic acid-based therapeutics to restore joint homeostasis in age-related and post-traumatic arthritis.

Muhammad Farooq Rai, Christine Tn Pham, Kirk Hou, Samuel A Wickline, Hua Pan

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in npj biomedical innovations, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Muhammad Farooq RaiDepartment of Biological Sciences, College of Medicine and Health Sciences, Khalifa University, Abu Dhabi, UAE.
Christine Tn PhamDivision of Rheumatology, Department of Medicine, Washington University School of Medicine, St. Louis, MO USA.
Kirk HouDepartment of Ophthalmology, Stein and Doheny Eye Institutes, University of California, Los Angeles, CA USA.
Samuel A WicklineDivision of Rheumatology, Department of Medicine, Washington University School of Medicine, St. Louis, MO USA.
Hua PanDivision of Rheumatology, Department of Medicine, Washington University School of Medicine, St. Louis, MO USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Osteoarthritis, a complex genetic disease, involves disrupted joint homeostasis driven by catabolic and inflammatory processes. Traditional therapies offer limited success. This review explores nucleic acid-based therapeutics-siRNA, miRNA, and mRNA-as a promising strategy for restoring balance by modulating gene expression. Nanoplatforms enable precise delivery of these molecules, offering potential for disease-modifying interventions. Emphasis is placed on advancing RNA therapies tailored to the disease stage for effective disease management.

Indexed as

Biological techniquesMolecular medicineRheumatology

Identifiers

PMID41769202
PMCPMC12948671

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.