ReviewArrhythmia & electrophysiology review2026
Impacts of Cardiac Dyssynchrony and Resynchronisation on Cellular Metabolism and Mitochondria: Current Understanding for Future Applications.
Review in Arrhythmia & electrophysiology review, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
5 authors.
Funding
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Abstract
Ventricular dyssynchrony serves as a cause of heart failure, resulting from impaired electrical conduction within the heart, commonly from bundle branch block or right ventricular pacing. It exceeds structural remodelling to cause significant cellular dysfunction, particularly in aberrant myocardial metabolism, alterations to myocardial oxygen consumption and cardiac efficiency, along with compromised mitochondrial activity. CRT is a therapeutic strategy that is used for the dyssynchronous ventricle by correcting electrical aberrance, while also improving cellular metabolic homeostasis, cardiac efficiency and mitochondrial function. This article provides a comprehensive review of the mechanisms responsible for ventricular dyssynchrony-induced cardiac remodelling and its reversal through cardiac resynchronisation therapy, focusing on the influence that these mechanisms exert on cellular metabolism and mitochondrial function. Additionally, it underscores the potential for risk assessment and individualised treatment targeting in dyssynchronous heart failure, using metabolic profiles, mitochondrial function indicators and metabolomic evaluation to enhance the efficacy of CRT and improve patient outcomes.
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