Evidence map›Paper›PMID 41769178›Full record

ArticleJPhys photonics2026

Enhanced accuracy of NIRS-vascular occlusion testing through incorporation of conduit artery diameter.

Soongho Park, Julie Mathew, Eric Leifer, Sharon Osgood, Claudia Gomez, Hans Ackerman, Yogendra Kanthi

2 registry-linked trialsAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JPhys photonics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03538639 recruitingnot on this map

Vascular Disease Discovery Protocol

TypeobservationalSponsorNational Heart, Lung, and Blood Institute (NHLBI)Ran2018 to 2037Enrolled1,000ConditionsVascular Dysfunction, Genetic Mutations, Genetic Predisposition
NCT06552767 recruitingnot on this map

Thrombosis and Inflammation in Vessels Initiative (TIVI)

TypeobservationalSponsorNational Heart, Lung, and Blood Institute (NHLBI)Ran2024 to 2034Enrolled1,000ConditionsCardiovascular Diseases, Vascular Diseases
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Soongho ParkDivision of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, 10 Center Dr, Bethesda, MD 20814, United States of America.ORCID https://orcid.org/0000-0001-8771-8397
Julie MathewDivision of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, 10 Center Dr, Bethesda, MD 20814, United States of America.
Eric LeiferDivision of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, 10 Center Dr, Bethesda, MD 20814, United States of America.
Sharon OsgoodDivision of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, 10 Center Dr, Bethesda, MD 20814, United States of America.
Claudia GomezDivision of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, 10 Center Dr, Bethesda, MD 20814, United States of America.
Hans AckermanIntramural Research Program, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 10 Center Dr, Bethesda, MD 20814, United States of America.ORCID https://orcid.org/0000-0003-4940-3305
Yogendra KanthiDivision of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, 10 Center Dr, Bethesda, MD 20814, United States of America.ORCID https://orcid.org/0000-0002-5660-5194

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Near-infrared spectroscopy with vascular occlusion testing (NIRS-VOT) offers a non-invasive approach for real-time assessment of tissue oxygenation and vascular function. However, its clinical application remains limited, in part due to substantial inter-individual variability in anatomical and physiological characteristics. To identify potential sources of variability, we explored whether incorporating conduit artery size-specifically baseline brachial artery diameter (BrAD)-into the NIRS-VOT data analysis could enhance physiological interpretation and reduce measurement error. We analyzed NIRS-VOT responses from 16 healthy participants recruited to the NIH Clinical Center (NCT06552767 and NCT03538639), incorporating individual BrAD measurements as a covariate. Strong to moderate Spearman's rank-order correlations were observed between BrAD and dynamic perfusion parameters, including the desaturation rate (

Indexed as

brachial arteryhemodynamic parametersinter-individual variabilitymicrovascular reactivitynear-infrared spectroscopyquantitative vascular assessmentvascular occlusion test

Identifiers

PMID41769178
PMCPMC12946859

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.