Evidence map›Paper›PMID 41769153›Full record

ArticleJournal of biomedical optics2026

Cause, effect, and remediation of melanin-associated bias in pulse oximetry.

Kevin J Benner, Neha N Goel, Mark S Rea

Abstract read
In one paragraph

Article in Journal of biomedical optics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Kevin J BennerIcahn School of Medicine at Mount Sinai, Light and Health Research Center, Department of Population Health Science and Policy, New York, New York, United States.ORCID https://orcid.org/0000-0002-6897-654X
Neha N GoelIcahn School of Medicine at Mount Sinai, Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, New York, New York, United States.ORCID https://orcid.org/0000-0001-7295-2033
Mark S ReaIcahn School of Medicine at Mount Sinai, Light and Health Research Center, Department of Population Health Science and Policy, New York, New York, United States.ORCID https://orcid.org/0000-0001-8458-9876

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Significance: Black patients are at greater risk than White patients for occult hypoxemia due to a melanin-associated bias in Aim: We aim to demonstrate how melanin-associated inaccuracies in commercially available pulse oximeters increase the likelihood of occult hypoxemia for all patients and how monochromatic light sources could minimize melanin-associated occult hypoxemia. Approach: Published values of mean error ( Results: The analytically predicted risk of occult hypoxemia for Black patients relative to White patients was 2.1, consistent with published empirical findings. Oximeters unaffected by melanin in the skin would have smaller mean errors and uncertainties than current oximeters, significantly reducing the risk of occult hypoxemia in both Black patients (83% reduction) and White patients (65% reduction). Conclusions: Because everyone has melanin in their skin, the use of monochromatic light sources in pulse oximeters could significantly reduce the risk of occult hypoxemia for everyone.

Indexed as

MelaninsOximetryBlack PeopleHumansHypoxiaOxygenOxygen SaturationSkinWhite PeopleMelaninsOxygenmelanin biasoccult hypoxemiaoximetryprecision

Identifiers

PMID41769153
PMCPMC12945331

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.