ArticleBiomedical optics express2025
Vacuum-based specimen holder for rapid surgical specimen imaging.
Article in Biomedical optics express, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Diagnostic accuracy of two-photon fluorescence microscopy in Mohs surgery of basal cell carcinomas.Journal of the American Academy of Dermatology · 2026Article
- Slide-free, point-of-care imaging of core needle biopsies for rapid histologic assessment.Biomedical optics express · 2026Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Slide-free histology enables rapid evaluation of tissue specimens but can be challenging to perform on curved or beveled surfaces, as are common in surgical excisions. In applications such as intraoperative margin evaluation during Mohs surgery, the full margin of the excised surface needs to be imaged, which requires a high degree of surface flattening. We introduce a vacuum-based specimen holder that achieves a mean 96% margin coverage for slide-free histology of Mohs specimens performed intraoperatively. Moreover, the open-top design allows for manipulation to correct folds and beveled edges associated with excisions during real-time imaging, enabling rapid correction of obscured areas of tissue. Finally, compared to existing positive pressure-based holders, the vacuum-based holder exerts no force onto the optical window during imaging, which enables the use of thin optical windows and removes optical deflection caused by pressure while providing an extremely flat imaging surface.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.