Evidence map›Paper›PMID 41769002›Full record

ArticleFrontiers in cell and developmental biology2026

Enhancing antioxidant capacity via NRF2 pathway activation to mitigate heat stress-induced oxidative damage in bovine granulosa cells, oocytes, and embryos.

Ghyslaine G Ramírez, Ahmed Gad, Nico G Menjivar, Scott Burlingham, Ming-Hao Cheng, Thomas W Chen, Soham Ghosh, Dawit Tesfaye

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cell and developmental biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ghyslaine G RamírezAnimal Reproduction and Biotechnology Laboratory (ARBL), Department of Biomedical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, United States.
Ahmed GadAnimal Reproduction and Biotechnology Laboratory (ARBL), Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, United States.
Nico G MenjivarAnimal Reproduction and Biotechnology Laboratory (ARBL), Department of Biomedical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, United States.
Scott BurlinghamCellular Engineering and Mechanobiology Laboratory (CEML), Translational Medicine Institute (TMI), Department of Mechanical Engineering, Colorado State University, Fort Collins, CO, United States.
Ming-Hao ChengDepartment of Electrical & Computer Engineering, Colorado State University, Fort Collins, CO, United States.
Thomas W ChenDepartment of Electrical & Computer Engineering, Colorado State University, Fort Collins, CO, United States.
Soham GhoshCellular Engineering and Mechanobiology Laboratory (CEML), Translational Medicine Institute (TMI), Department of Mechanical Engineering, Colorado State University, Fort Collins, CO, United States.
Dawit TesfayeAnimal Reproduction and Biotechnology Laboratory (ARBL), Department of Biomedical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Global warming-induced thermal stress is an escalating threat to livestock fertility, perturbing ovarian function, oocyte maturation, and preimplantation embryo development through excessive accumulation of reactive oxygen species (ROS), which drive follicular oxidative damage. Although embryo transfer technologies offer a practical abatement strategy for mitigating such implications caused by HS,

Indexed as

antioxidantsembryonic developmentgranulosa cellsheat stressNRF2 pathwayoocyte maturationquercetinsulforaphane

Identifiers

PMID41769002
PMCPMC12936007

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.