Evidence map›Paper›PMID 41768982›Full record

ArticleEClinicalMedicine2026

Minimum combined sleep, physical activity, and nutrition variations associated with lifeSPAN and healthSPAN improvements: a population cohort study.

Nicholas A Koemel, Raaj K Biswas, Matthew N Ahmadi, Armando Teixeira-Pinto, Mark Hamer, Leandro F M Rezende, John Mitchell, Rebecca M Leech, Mouna Sawan, Margaret Allman-Farinelli and 12 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EClinicalMedicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Nicholas A KoemelMackenzie Wearables Research Hub, Charles Perkins Centre, University of Sydney, Sydney, NSW, Australia.
Raaj K BiswasMackenzie Wearables Research Hub, Charles Perkins Centre, University of Sydney, Sydney, NSW, Australia.
Matthew N AhmadiMackenzie Wearables Research Hub, Charles Perkins Centre, University of Sydney, Sydney, NSW, Australia.
Armando Teixeira-PintoCentre for Precision Data Science, University of Sydney, Sydney, NSW, Australia.
Mark HamerDivision of Surgery and Interventional Science, Institute Sport Exercise and Health, University College London, London, United Kingdom.
Leandro F M RezendeDepartment of Preventive Medicine, Chronic Disease Epidemiology Research Center, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil.
John MitchellDivision of Surgery and Interventional Science, Institute Sport Exercise and Health, University College London, London, United Kingdom.
Rebecca M LeechInstitute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Deakin, Geelong, VIC, Australia.
Mouna SawanSchool of Pharmacy, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia.
Margaret Allman-FarinelliCharles Perkins Centre, University of Sydney, Sydney, NSW, Australia.
Dorothea DumuidAlliance for Research in Exercise, Nutrition and Activity, Allied Health and Human Performance, University of South Australia, Adelaide, SA, Australia.
Adrian BaumanCharles Perkins Centre, University of Sydney, Sydney, NSW, Australia.
Carol MaherAlliance for Research in Exercise, Nutrition and Activity, Allied Health and Human Performance, University of South Australia, Adelaide, SA, Australia.
Stephen BarrettBendigo Health and Holsworth Research Initiative, La Trobe Rural Health School, Bendigo, VIC, Australia.
Clara ChowWestmead Applied Research Centre, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia.
Alice A GibsonCharles Perkins Centre, University of Sydney, Sydney, NSW, Australia.
David RaubenheimerCharles Perkins Centre, University of Sydney, Sydney, NSW, Australia.
Samantha L HockingCharles Perkins Centre, University of Sydney, Sydney, NSW, Australia.
Kathryn WilliamsCharles Perkins Centre, University of Sydney, Sydney, NSW, Australia.
Peter A CistulliCharles Perkins Centre, University of Sydney, Sydney, NSW, Australia.
Stephen J SimpsonCharles Perkins Centre, University of Sydney, Sydney, NSW, Australia.
Emmanuel StamatakisMackenzie Wearables Research Hub, Charles Perkins Centre, University of Sydney, Sydney, NSW, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Sleep, physical activity, and nutrition (SPAN) are key determinants of both life expectancy (lifespan) and disease-free life expectancy (healthspan), yet are often studied in isolation. This study aimed to determine the minimum combined SPAN improvements needed for a longer lifespan and healthspan. Methods: This prospective cohort comprised 59,078 participants from the UK Biobank, recruited between 2006 and 2010 (median age: 64.0 years; 45.4% male). Between 2013 and 2015, a subsample of participants was invited to wear a wrist worn accelerometer for 7 days. Moderate to vigorous physical activity (MVPA; mins/day) and sleep (hours/day) were calculated using a validated wearables-based algorithm. Diet was assessed using a 10-item diet quality score (DQS), including intake of vegetables, fruits, grains, meats, fish, dairy, oils, and sugar-sweetened beverages (ranging 0-100; higher indicates better quality). Lifespan and healthspan (free of cardiovascular disease (CVD), cancer, type II diabetes, chronic obstructive pulmonary disease (COPD), and dementia) were estimated across 27 joint tertile SPAN combinations and a composite SPAN score using life tables. Findings: Over an 8.1-year median follow-up, 2458 deaths, 9996 CVD, 7681 cancers, 2971 type II diabetes, 1540 COPD, and 508 dementia events occurred. Compared to the least favourable tertiles, the optimal tertiles (7.2-8.0 h/day of sleep; >42 min/day of MVPA; DQS of 57.5-72.5) had 9.35 additional years of lifespan (95% CI: 6.67, 11.63) and 9.45 years of healthspan (95% CI: 5.45, 13.61). Compared to the 5th percentile, a minimum combined improvement of 5 min/day of sleep, 1.9 min/day MVPA, and a 5-point increase in DQS (e.g., additional ½ serving of vegetables/day or additional 1.5 servings of whole grains per day) was associated with 1 additional year of lifespan (95% CI: 0.69, 1.15). For healthspan, a combined improvement of 24 min/day of sleep, 3.7 min/day of MVPA, and a 23-point DQS increase was associated with 4.0 additional years (95% CI: 0.50, 8.61). Interpretation: Modest concurrent improvements in sleep, physical activity, and diet were associated with meaningful gains in lifespan and healthspan. Funding: Australian National Health and Medical Research Council.

Indexed as

DietDisease free life expectancyExerciseHealthspanLife expectancyLifespanLifestyle risk factorsNutritionPhysical activitySleep

Identifiers

PMID41768982
PMCPMC12947648

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.