ArticleNAR molecular medicine2026
Altered transposon element-derived genes distort oxygen-free radical scavenger systems in FXD.
Article in NAR molecular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Chromatin dynamics and cellular energy homeostasis.Journal of biochemistry · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The altered expression of transposon element (TE)-derived genes that regulate immune responses implied the involvement of previous viral infections in the onset of Fragile X disorders (FXD), often bearing sustained inflammation. Here, we discovered that hypoxia greatly modifies the expression of TE-derived genes that act as oxygen-free radical scavengers, resulting in an alkylating environment under normoxia in FXD. Molybdenum cofactor synthesis 3 (MOCS3) and selenocysteine lyase (SCLY) stabilize the association of Kelch-like ECH-associated protein 1 (KEAP1) with PGAM family member 5 (PGAM5). This rewires connections between the oxidative stress response, cysteine-sulfur and selenium metabolism, and oxidoreductases. Desensitized tRNA thiolation against hypoxia in FXD suggests that the rewired radical scavenging system induces resistance to ROS in FXD.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.