Competitive Inhibition as a Tool to Modulate and Predict Dynamic Hydrogel Mechanics.

Alexander D Claiborne, Sirilak Mekcham, Owen A Lee, Megan R Hill

Abstract read

In one paragraph

Article in ACS central science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Alexander D ClaiborneDepartment of Chemistry, Colorado State University, 301 W Pitkin St., Fort Collins, Colorado 80521, United States.ORCID https://orcid.org/0009-0008-8150-4679

Sirilak MekchamDepartment of Chemistry, Colorado State University, 301 W Pitkin St., Fort Collins, Colorado 80521, United States.

Owen A LeeDepartment of Chemistry, Colorado State University, 301 W Pitkin St., Fort Collins, Colorado 80521, United States.ORCID https://orcid.org/0000-0002-4340-2267

Megan R HillDepartment of Chemistry, Colorado State University, 301 W Pitkin St., Fort Collins, Colorado 80521, United States.ORCID https://orcid.org/0000-0001-7025-1073

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dynamic hydrogels are powerful biomaterials whose performance in drug delivery, tissue engineering, and related applications depends on mechanical properties that remain difficult to predict. We introduce a simple, quantitative framework for tuning hydrogel mechanics through competitive inhibition, where small-molecule competitors reversibly disrupt cross-linking. Inspired by Michaelis-Menten kinetics, the model defines an apparent cross-link association constant,

Identifiers

PMID41768768

DOI10.1021/acscentsci.5c02130

PMCPMC12947549

What OpenQuestion holds

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LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.