Evidence map›Paper›PMID 41768731›Full record

ArticleACS omega2026

Cytotoxicity and Cellular Mechanisms of Novel Polymeric 2,4D Nanopesticide on Human Lung Epithelial A549 Cells.

Ching-Yee Loo, Wing-Hin Lee, Nor Fadilah Rajab, Ee-Ling Siew

Abstract read
In one paragraph

Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ching-Yee LooFaculty of Pharmacy and Health Sciences, Royal College of Medicine Perak, Universiti Kuala Lumpur (UniKL RCMP), 30450 Ipoh, Perak, Malaysia.
Wing-Hin LeeFaculty of Pharmacy and Health Sciences, Royal College of Medicine Perak, Universiti Kuala Lumpur (UniKL RCMP), 30450 Ipoh, Perak, Malaysia.ORCID https://orcid.org/0000-0003-0212-6523
Nor Fadilah RajabBiomedical Science Programme, Center for Healthy Aging and Wellness, Faculty of Allied Health Sciences, Universiti Kebangsaan Malaysia, 50300 Kuala Lumpur, Malaysia.
Ee-Ling SiewASASIpintar Unit, Pusat PERMATA@Pintar Negara, Universiti Kebangsaan Malaysia, 43600 Bangi, Selangor, Malaysia.ORCID https://orcid.org/0000-0002-3420-5114

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nanotechnology offers promising ecosustainable solutions for crop protection, but the use of nanopesticides, such as 2,4-dichlorophenoxyacetic acid-loaded polymeric nanopesticides (2,4D-NPs), presents significant human health risks, particularly via inhalation. This study was carried out to assess the cytotoxicity and underlying mechanisms of 2,4D-NPs on human lung epithelial A549 cells, which were selected as a representative model for the primary site of inhalation exposure. The synthesized 2,4D-NPs were well-defined spherical particles with an average size of approximately 49 nm, a negative ζ potential, and high encapsulation efficiency, confirming successful nanoformulation. Cytotoxicity assessments showed that the 2,4D-NPs had a significantly enhanced effect compared to raw 2,4D, with an IC

Identifiers

PMID41768731
PMCPMC12946842

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.