Evidence map›Paper›PMID 41768728›Full record

ArticleACS omega2026

Correlation between NFκB Signaling and Na

Ketlyn Pereira da Motta, Carolina Cristóvão Martins, Vanessa Macedo Esteves da Rocha, Ingrid Cardoso Oliveira, Diego Alves, Larissa Daniele Bobermin, André Quincozes-Santos, Ethel Antunes Wilhelm

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ketlyn Pereira da MottaGraduate Program in Biochemistry and Bioprospecting, Preclinical and Translational Research Group on Pain and Chronic Diseases, CCQFA, Federal University of Pelotas (UFPel), P.O., Box 354, 96010-900 Pelotas, Rio Grande do Sul, Brazil.
Carolina Cristóvão MartinsGraduate Program in Biochemistry and Bioprospecting, Preclinical and Translational Research Group on Pain and Chronic Diseases, CCQFA, Federal University of Pelotas (UFPel), P.O., Box 354, 96010-900 Pelotas, Rio Grande do Sul, Brazil.
Vanessa Macedo Esteves da RochaGraduate Program in Biochemistry and Bioprospecting, Preclinical and Translational Research Group on Pain and Chronic Diseases, CCQFA, Federal University of Pelotas (UFPel), P.O., Box 354, 96010-900 Pelotas, Rio Grande do Sul, Brazil.
Ingrid Cardoso OliveiraGraduate Program in Chemistry, Clean Organic Synthesis Laboratory, CCQFA, Federal University of Pelotas (UFPel), P.O., Box 354 96010-900 Pelotas, Rio Grande do Sul, Brazil.
Diego AlvesGraduate Program in Chemistry, Clean Organic Synthesis Laboratory, CCQFA, Federal University of Pelotas (UFPel), P.O., Box 354 96010-900 Pelotas, Rio Grande do Sul, Brazil.
Larissa Daniele BoberminGraduate Program in Biological Sciences: Biochemistry, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul (UFRGS), 90035-003 Porto Alegre, Rio Grande do Sul, Brazil.
André Quincozes-SantosGraduate Program in Biological Sciences: Biochemistry, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul (UFRGS), 90035-003 Porto Alegre, Rio Grande do Sul, Brazil.
Ethel Antunes WilhelmGraduate Program in Biochemistry and Bioprospecting, Preclinical and Translational Research Group on Pain and Chronic Diseases, CCQFA, Federal University of Pelotas (UFPel), P.O., Box 354, 96010-900 Pelotas, Rio Grande do Sul, Brazil.ORCID https://orcid.org/0000-0002-2875-9962

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vincristine (VCR), a widely used chemotherapeutic agent, is associated with persistent neurotoxic effects including psychiatric and cognitive impairments in cancer survivors. In contrast, 7-chloro-4-(phenylselanyl)-quinoline (4-PSQ) is a synthetic compound with potential neuroprotective effects. This study investigated the neurobehavioral and molecular effects of VCR in male and female Swiss mice, with a focus on sex-specific outcomes and the neuroprotective efficacy of 4-PSQ. Mice received daily intraperitoneal injections of VCR (0.1 mg/kg) or vehicle (0.9% saline solution) for 5 days, followed by daily oral administration of 4-PSQ (1 mg/kg) or vehicle (canola oil) from days 7 to 16. Behavioral assessments for depressive- and anxiety-like responses and cognitive performance were conducted, followed by biochemical analyses of the cerebral cortex and spinal cord. VCR significantly increased nuclear factor kappa B (NFκB) expression and inhibited Na

Identifiers

PMID41768728
PMCPMC12947186

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.