ArticleACS omega2026
Spontaneous Emulsification as a Low-Energy Strategy for Designing and Optimizing Resveratrol-Loaded Nanostructured Lipid Carriers.
Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Nano-engineered phytochemicals in cancer therapy: mechanistic insights into apoptosis, ferroptosis, tumor microenvironment modulation and drug resistance reversal.Apoptosis : an international journal on programmed cell death · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nanostructured lipid carriers (NLCs) have proven to be effective for the delivery of lipophilic drugs by combining high encapsulation capacity with controlled release properties. In this study, NLCs were developed using spontaneous emulsification, a low-energy, simple method that is free of organic solvents. Cetearyl alcohol and Kolliphor RH 40 were employed as the solid lipid and surfactant, respectively. The formulation and process were optimized through a Box-Behnken design, considering mean particle size and size uniformity, as determined by laser diffraction. Colloidal stability was improved by the addition of sodium lauryl sulfate and adjustments to the dispersion polymer. Resveratrol (RVL), used as a model bioactive compound, achieved an encapsulation efficiency of 99%, with a mean particle size of 90 nm, a polydispersity index of 0.2, and a zeta potential of -37 mV, remaining stable for 90 days at 8 °C. Characterization by differential scanning calorimetry/thermogravimetry, Fourier transform infrared, and transmission electron microscopy confirmed the incorporation of the active compound as well as the composition and morphology of the nanocarriers. The system exhibited a delayed and sustained release of RVL, highlighting its potential as a platform for the delivery of bioactive compounds. Overall, the results demonstrate that spontaneous emulsification is a viable and sustainable alternative to the high-energy methods predominantly reported in the literature, enabling the production of stable and efficient NLCs for pharmaceutical and cosmetic applications.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.