Evidence map›Paper›PMID 41768659›Full record

ArticleACS omega2026

Antispasmodic Activity of Green-Synthesized Phenylaminojuglones: In Vitro and In Silico Studies.

Daniel Asunción-Alvarez, Roberto O Ybañez-Julca, Gabriela Y Paredes-Doroteo, Iván M Quispe-Díaz, Elena Mantilla-Rodríguez, Cinthya Enriquez-Lara, Edison Vásquez-Corales, Pedro Buc Calderon, Marcelo A Catalán, Wilfredo O Gutiérrez-Alvarado and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Daniel Asunción-AlvarezGrupo de Investigación en Estudios de Compuestos Naturales y Sintéticos con Actividad a Nivel Sistema Nervioso Central y Musculo Liso, Laboratorio de Farmacología. Facultad de Farmacia y Bioquímica, Universidad Nacional de Trujillo, Trujillo 13011, Peru.
Roberto O Ybañez-JulcaGrupo de Investigación en Estudios de Compuestos Naturales y Sintéticos con Actividad a Nivel Sistema Nervioso Central y Musculo Liso, Laboratorio de Farmacología. Facultad de Farmacia y Bioquímica, Universidad Nacional de Trujillo, Trujillo 13011, Peru.
Gabriela Y Paredes-DoroteoGrupo de Investigación en Estudios de Compuestos Naturales y Sintéticos con Actividad a Nivel Sistema Nervioso Central y Musculo Liso, Laboratorio de Farmacología. Facultad de Farmacia y Bioquímica, Universidad Nacional de Trujillo, Trujillo 13011, Peru.
Iván M Quispe-DíazGrupo de Investigación en Estudios de Compuestos Naturales y Sintéticos con Actividad a Nivel Sistema Nervioso Central y Musculo Liso, Laboratorio de Farmacología. Facultad de Farmacia y Bioquímica, Universidad Nacional de Trujillo, Trujillo 13011, Peru.
Elena Mantilla-RodríguezGrupo de Investigación en Estudios de Compuestos Naturales y Sintéticos con Actividad a Nivel Sistema Nervioso Central y Musculo Liso, Laboratorio de Farmacología. Facultad de Farmacia y Bioquímica, Universidad Nacional de Trujillo, Trujillo 13011, Peru.
Cinthya Enriquez-LaraPrograma de Doctorado en Química Medicinal, Facultad de Ciencias de La Salud, Universidad Arturo Prat, Casilla 121, Iquique 1100000, Chile.
Edison Vásquez-CoralesTalleres y Laboratorio, Universidad Católica Los Ángeles de Chimbote, Chimbote 02801, Peru.
Pedro Buc CalderonPrograma de Doctorado en Química Medicinal, Facultad de Ciencias de La Salud, Universidad Arturo Prat, Casilla 121, Iquique 1100000, Chile.
Marcelo A CatalánInstituto de Fisiología, Facultad de Medicina, Universidad Austral de Chile, Valdivia 5090000, Chile.
Wilfredo O Gutiérrez-AlvaradoFacultad de Farmacia y Bioquímica, Universidad Nacional de La Amazonía Peruana, Iquitos 16001, Peru.
Julio BenitesPrograma de Doctorado en Química Medicinal, Facultad de Ciencias de La Salud, Universidad Arturo Prat, Casilla 121, Iquique 1100000, Chile.ORCID https://orcid.org/0000-0002-8562-0078

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Phenylaminojuglones were synthesized under solvent-free conditions via silica gel-mediated aza-Michael addition between juglone and substituted anilines, namely, aniline, 4-methoxyaniline, and 3,4,5-trimethoxyaniline. Among the synthesized derivatives, phenylaminojuglone (

Identifiers

PMID41768659
PMCPMC12946952

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.