ArticleACS omega2026
Multifunctional Hydrogel with Dual Functions of ROS Scavenging and Responsive Antibiotic Release for Synergistic Oral Mucositis Treatment.
Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- From Infection Control to Tissue Regeneration: Mechanisms, Design Strategies, and Smart Advances in Antibacterial Hydrogels.Gels (Basel, Switzerland) · 2026Review
- Advances in Nanozyme Engineering for Precision Oral Health Management.International dental journal · 2026Review
- Hydrogels for Healing Radiation-Injured Tissues and Organs.Gels (Basel, Switzerland) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Radiotherapy- and chemotherapy-induced oral mucositis (OM), characterized by high incidence and delayed healing, significantly impacts patient recovery and quality of life. Current clinical management of OM wounds remains unsatisfactory, primarily due to the risks of oxidative damage and bacterial infection during the healing process. To address this challenge, we developed a multifunctional hydrogel (QTMP-Gel) based on dynamic cross-linking between quaternary ammonium chitosan (QCS) and tannic acid (TA). This QCS-TA matrix provides robust adhesion to wet oral mucosa and enables ROS-responsive drug release. The hydrogel is coloaded with two active components: platinum nanoparticles, which exhibit catalase-like activity for efficient and sustained ROS scavenging, and the broad-spectrum antibiotic minocycline hydrochloride, which provides synergistic antibacterial and anti-inflammatory effects. In vitro assays demonstrated excellent biocompatibility, remarkable antioxidant capacity, and effective inhibition of
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.