Nicotinamide Mononucleotide Decreases Secretion of Proinflammatory Cytokines via the NAD

Dongyuan Zhang, Zhiqiang Li, Xianbin Meng, Tianxiang Wang, Zelong Miao, Haiteng Deng

Abstract read

In one paragraph

Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Dongyuan ZhangMOE Key Laboratory of Bioinformatics, State Key Laboratory of Complex, Severe, and Rare Diseases, School of Life Sciences, Tsinghua University, Beijing 100084, China.

Zhiqiang LiMOE Key Laboratory of Bioinformatics, State Key Laboratory of Complex, Severe, and Rare Diseases, School of Life Sciences, Tsinghua University, Beijing 100084, China.

Xianbin MengMOE Key Laboratory of Bioinformatics, State Key Laboratory of Complex, Severe, and Rare Diseases, School of Life Sciences, Tsinghua University, Beijing 100084, China.

Tianxiang WangMOE Key Laboratory of Bioinformatics, State Key Laboratory of Complex, Severe, and Rare Diseases, School of Life Sciences, Tsinghua University, Beijing 100084, China.

Zelong MiaoMOE Key Laboratory of Bioinformatics, State Key Laboratory of Complex, Severe, and Rare Diseases, School of Life Sciences, Tsinghua University, Beijing 100084, China.

Haiteng DengMOE Key Laboratory of Bioinformatics, State Key Laboratory of Complex, Severe, and Rare Diseases, School of Life Sciences, Tsinghua University, Beijing 100084, China.ORCID https://orcid.org/0000-0001-9496-1280

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Senescence-associated secretory phenotype (SASP) is a typical trait of senescent cells that contributes to aging and chronic diseases. Consequently, SASP is considered a potential antiaging target. Senomorphics are small molecules that cause SASP blockage to provide effective antiaging interventions. The identification and discovery of senomorphics is an extremely promising new branch of antiaging research. In this study, we found that nicotinamide mononucleotide (NMN) efficiently inhibits the secretion of multiple proinflammatory cytokines by senescent cells. We further showed that supplementation with NMN significantly increases NAD

Identifiers

PMID41768621

DOI10.1021/acsomega.5c09277

PMCPMC12946971

What OpenQuestion holds

Textmetadata

LicenceCC BY-NC-ND

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.