Evidence map›Paper›PMID 41768567›Full record

ArticleMacromolecules2025

Mechanistic Origins of Yielding in Hybrid Double-Network Hydrogels.

Vinay Kopnar, Adam O'Connell, Natasha Shirshova, Anders Aufderhorst-Roberts

Abstract read
In one paragraph

Article in Macromolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Vinay KopnarDepartment of Physics, Durham University, Lower Mountjoy, South Rd, Durham DH1 3LE, U.K.
Adam O'ConnellPolymer Science Platform, Reckitt Benckiser Health Care UK Ltd, Dansom Lane S, Hull HU8 7DS, U.K.ORCID https://orcid.org/0000-0002-1904-9168
Natasha ShirshovaDepartment of Engineering, Durham University, Lower Mountjoy, South Rd, Durham DH1 3LE, U.K.
Anders Aufderhorst-RobertsDepartment of Physics, Durham University, Lower Mountjoy, South Rd, Durham DH1 3LE, U.K.ORCID https://orcid.org/0000-0003-3559-9423

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hybrid double-network hydrogels comprise transiently and permanently cross-linked polymer networks and exhibit enhanced toughness, arising from a local yielding transition. Here, we examine the precise nature of this yielding transition by constructing a series of hydrogel designs from alginate and polyacrylamide (PAAm) networks, systematically controlling their cross-linking chemistry. Using large amplitude oscillatory shear (LAOS) rheology (LAOS), we show the presence of a hitherto unobserved two-step yielding process. Analysis of individual oscillatory cycles and the use of chaotropic/kosmotropic reagents shows that the first step of yielding is determined by the hydrogen bonding

Identifiers

PMID41768567
PMCPMC12392726

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.