ArticleDEN open2026
Evaluation of Delayed Bleeding Prevention and Sustained Closure Using the Reopenable Clip-Over-the-Line Method for Gastric Endoscopic Submucosal Dissection.
Article in DEN open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Comparison of vonoprazan and proton pump inhibitors for the management of gastric post-endoscopic submucosal dissection ulcers and preventing delayed bleeding: a meta-analysis of randomized controlled trials.Frontiers in medicine · 2026Pooled it
- The Hedgehog Method Following Gastric Endoscopic Submucosal Dissection: Observed Postoperative Bleeding Rates Across BEST-J Risk Categories.Digestive diseases and sciences · 2026Article
- Endoscopic Closure After Colorectal ESD: A Literature Review and Meta-Analysis on Its Efficacy in Preventing Adverse Events.Diagnostics (Basel, Switzerland) · 2026Review
- Establishment and validation of a predictive scoring system for titanium clip retention at six months after endoscopic submucosal dissection for gastric lesions.Scientific reports · 2026Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives: Delayed bleeding is a major complication of gastric endoscopic submucosal dissection (ESD), particularly in high-risk patients. The reopenable clip-over-the-line method (ROLM) is a novel closure technique, but its durability and preventive effects remain unclear. We evaluated the impact of ROLM on delayed bleeding and sustained closure after gastric ESD in high-risk patients. Methods: We retrospectively reviewed gastric ESD cases from April 2021 to December 2024, including only patients with a BEST-J score ≥3, and compared ROLM and non-ROLM groups. In the ROLM group, mucosal closure was confirmed endoscopically on postoperative day 1 (POD1), and clip retention was assessed at 2 months. The primary outcome was delayed bleeding within 28 days. Secondary outcomes included sustained closure on POD1 and clip retention at 2 months. Results: The ROLM group included 21 lesions in 15 patients, and the non-ROLM group included 93 lesions in 72 patients. Delayed bleeding occurred in 0/15 ROLM patients (0%) versus 17/72 non-ROLM patients (23.6%) ( Conclusion: In high-risk gastric ESD patients, ROLM was associated with no delayed bleeding and achieved complete POD1 closure with frequent 2-month clip retention, suggesting a potential for a promising prophylactic strategy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.