Evidence map›Paper›PMID 41768275›Full record

ArticleEClinicalMedicine2026

Legal blood alcohol concentration limits and alcohol-attributable traffic mortality rates: an analysis across 165 countries.

C Leonardo Jimenez Chavez, MacKenzie R Peltier, Abbie A Mokwuah, Amirah Bin-Mahfouz, Terril L Verplaetse, Yasmin Zakiniaeiz, Robert Kohler, Vernon Garcia-Rivas, Bubu A Banini, Nakul R Raval and 2 more

Abstract read
In one paragraph

Article in EClinicalMedicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

C Leonardo Jimenez ChavezYale School of Medicine, Department of Psychiatry, New Haven, CT, United States of America.
MacKenzie R PeltierYale School of Medicine, Department of Psychiatry, New Haven, CT, United States of America.
Abbie A MokwuahYale School of Medicine, Department of Psychiatry, New Haven, CT, United States of America.
Amirah Bin-MahfouzYale School of Medicine, Department of Psychiatry, New Haven, CT, United States of America.
Terril L VerplaetseYale School of Medicine, Department of Psychiatry, New Haven, CT, United States of America.
Yasmin ZakiniaeizYale School of Medicine, Department of Psychiatry, New Haven, CT, United States of America.
Robert KohlerYale School of Medicine, Department of Psychiatry, New Haven, CT, United States of America.
Vernon Garcia-RivasYale School of Medicine, Department of Psychiatry, New Haven, CT, United States of America.
Bubu A BaniniYale School of Medicine, Section of Digestive Diseases, New Haven, CT, United States of America.
Nakul R RavalYale School of Medicine, Department of Psychiatry, New Haven, CT, United States of America.
Brian PittmanYale School of Medicine, Department of Psychiatry, New Haven, CT, United States of America.
Sherry A McKeeYale School of Medicine, Department of Psychiatry, New Haven, CT, United States of America.

Funding

Yale-SCORE Resource Support CoreU54AA027989 · NIAAA · YALE UNIVERSITY · PI Ralitza Gueorguieva · 2020 to 2026
$13.0M
Novel GluN2BR Radioligand for PET Neuroimaging in Alcohol Use DisorderK99AA032043 · NIAAA · YALE UNIVERSITY · PI Nakul Ravi Raval · 2025 to 2026
$305k
NIAAA NIH HHS K99 AA032043NIAAA NIH HHS U54 AA027989
6 · The paper itself

Abstract

Background: Alcohol-impaired driving remains a leading cause of road traffic deaths worldwide, yet despite widespread adoption, the effectiveness of national blood alcohol concentration (BAC) limits across diverse structural conditions and population risks remains poorly understood. Methods: We conducted a cross-national multilevel analysis of 165 countries using 2019 data on alcohol-attributable traffic mortality rates (ATMRs), national legal BAC limits, and structural country-level indicators. The primary outcome was ATMRs, defined as age-standardized death rates per 100,000 population among individuals aged 15 and older. Key predictors included national BAC limits, sex, and their interaction. Models were adjusted for national income, healthcare system infrastructure, gender inequality, and per capita alcohol consumption. Findings: Lower national BAC limits were associated with lower ATMRs, with significantly stronger effects observed among males versus females (β = -2.58, p < 0.01). Structural factors, including lower national income (β = -0.31, p < 0.01), greater gender inequality (β = 1.61, p < 0.01), and higher alcohol consumption (β = 0.16, p < 0.001) each predicted higher ATMRs. Our final model explained 71% of the variance in ATMRs. Interpretation: ATMRs represent a preventable global burden, with World Health Organization (WHO) BAC guidelines being exceeded in ∼30% of countries examined. While lower BAC limits reduce ATMRs overall for both women and men, men experienced a disproportionately higher share of the mortality burden. Further reduction in ATMRs would be maximized by considering country-level structural factors. Funding: NIH T32AA029259(CLJC), U54AA027989(SAM), K01AA029706(YZ), R01AA030971(TLV), Office of the Assistant Secretary of Defense for Health Affairs W81XWH-22-2-0081, PASA3(MRP/AAM) and Veterans Affairs VISN1-CDA(MRP).

Indexed as

Alcohol-attributable mortalityAlcohol policyCross-national comparisonGlobal road safetyPublic health policy

Identifiers

PMID41768275
PMCPMC12945517

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.