ArticleFrontiers in oncology2026
Modified systemic immune-inflammatory index, modified systemic inflammatory response index and hemoglobin-albumin-lymphocyte-platelet score may serve as markers for evaluating the efficacy of neoadjuvant therapy in breast cancer patients.
Article in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Objective: To explore the evaluation value of the modified systemic immune-inflammatory index (mSII), modified systemic inflammatory response index (mSIRI) and hemoglobin-albumin-lymphocyte-platelet (HALP) score for the efficacy of neoadjuvant therapy (NAT) in breast cancer. Methods: A total of 343 breast cancer patients who received NAT at Meizhou People's Hospital from June 2016 to October 2023 were analyzed. Clinical and pathological data before treatment and peripheral blood detection indicators were collected. A response to NAT was defined as the achievement of pathological complete response (CR) or partial response (PR). mSII, mSIRI, and HALP score were calculated, and the receiver operating characteristic (ROC) curve analysis was used to evaluate the predictive efficacy of each indicator. The relationship between NAT efficacy and mSII, mSIRI, HALP was analyzed. Results: 179 patients (52.2%) showed no response to NAT, while 164 (47.8%) exhibited a response. The NAT-responsive group had a higher proportion of HER2-positive and TNBC subtypes compared with the nonresponsive group ( Conclusions: Elevated mSII, mSIRI, and low HALP score were associated with the effectiveness of NAT in breast cancer. mSII, mSIRI, and HALP score may serve as valuable predictive indicators for the effectiveness of neoadjuvant therapy in breast cancer.
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