ArticleFrontiers in oncology2026
Manganese modulates hepatocellular carcinoma cytotoxicity and doxorubicin sensitivity in a dose dependent manner.
Article in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality globally, characterized by decreased manganese (Mn) levels in tumor tissues compared to noncancerous liver tissues. Although manganese's role in enhancing immune responses and inhibiting tumor growth has been noted, its specific contribution to HCC development and its influence on drug sensitivity are not well defined. Methods: We assessed the viability of HCC cells treated with various concentrations of MnCl Results: Our study found that low MnCl Discussion: This research elucidates the impact of Mn²
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