Evidence map›Paper›PMID 41768176›Full record

SynthesisFrontiers in psychology2026

The neurobiology of internet addiction: a scoping review of developmental and gender-specific mechanisms.

Jun Jin, Hanrui Wei, Yan Chai, Linxiao Wu, Mengying Chen, Keya Ding

Abstract readSystematic Review
In one paragraph

Synthesis in Frontiers in psychology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jun JinSchool of Preschool Education, Luoyang Normal University, Luoyang, China.
Hanrui WeiSchool of Preschool Education, Luoyang Normal University, Luoyang, China.
Yan ChaiSchool of Preschool Education, Luoyang Normal University, Luoyang, China.
Linxiao WuSchool of Preschool Education, Luoyang Normal University, Luoyang, China.
Mengying ChenSchool of Preschool Education, Luoyang Normal University, Luoyang, China.
Keya DingShanghai Institute of Early Childhood Education, Shanghai Normal University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Internet addiction (IA) constitutes a significant public health challenge, yet the distinct influence of neurodevelopmental stage and gender on its neural substrates remains under-characterized. This scoping review systematically synthesizes neuroimaging evidence to identify convergent brain alterations across IA subtypes and to disentangle the specific neural signatures associated with age and gender. Methods: Following PRISMA-ScR guidelines, we reviewed peer-reviewed studies published between 2015 and 2025. Searches were conducted across PubMed, Web of Science, and PsycINFO, focusing on investigations that explicitly incorporated age or gender as analytical factors in examining IA-related structural or functional brain changes. Results: The synthesized evidence indicates that IA is consistently associated with abnormal gray matter volume (GMV), compromised white matter integrity (WMI), and functional dysregulation within the prefrontal cortex (PFC), cingulate gyrus, and reward networks. Developmentally, findings reveal distinct trajectories: adolescents exhibit heightened vulnerability in regions governing emotion regulation and executive control, reflecting a developmental mismatch; in contrast, adults display alterations more indicative of established habit formation and reward circuit remodeling. Gender-specific patterns are also evident: males typically manifest neural alterations linked to gaming behaviors and impulse control, whereas females exhibit distinct profiles involving social-emotional processing networks. Conclusion: These findings confirm that IA pathology is not uniform but is significantly modulated by demographic factors. The evidence highlights the necessity of shifting from generalized approaches to prevention and intervention strategies that are tailored to specific developmental windows and gender profiles. Future research must prioritize longitudinal and multimodal designs to move from descriptive mapping to causal mechanistic understanding.

Indexed as

adolescenceadultsbrain structuregender differencesinternet addiction

Identifiers

PMID41768176
PMCPMC12935950

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.