ArticleJHEP reports : innovation in hepatology2026
Plasma GPC3 reflects tumor GPC3 expression and predicts clinical outcomes in advanced HCC treated with atezolizumab + bevacizumab.
Article in JHEP reports : innovation in hepatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background & Aims: The membrane proteoglycan glypican-3 (GPC3) is expressed in ∼70%-80% of hepatocellular carcinomas (HCCs), and its soluble fragment is released into the circulation by protease cleavage. We investigated correlations between tumor and plasma GPC3 levels and their associations with clinical outcomes in advanced HCC. Methods: We analyzed 186 patients with advanced HCC treated between 2017 and 2023. Tumor GPC3 expression was assessed using immunohistochemistry and RNA sequencing, and plasma GPC3 by ELISA. Clinical outcomes were investigated in 106 patients receiving first-line atezolizumab plus bevacizumab. Results: Plasma GPC3 was detectable in 59.3% of patients (median 11.4 pg/ml), and correlated with tumor expression (H-score: R = 0.40, Conclusions: While plasma GPC3 levels showed moderate concordance with tumor expression, meaningful discrepancies were also noted in a significant fraction of patients. High plasma GPC3 independently predicted worse survival outcomes in patients treated with atezolizumab plus bevacizumab, showing superior prognostic performance over tumor-based measures. Impact and implications: Glypican-3 (GPC3) is a promising biomarker and therapeutic target in hepatocellular carcinoma (HCC), yet the relationship between plasma and tumor GPC3 levels remains unclear, and their clinical relevance has not been well defined, particularly in patients receiving atezolizumab plus bevacizumab. Our study provides clinical evidence supporting plasma GPC3 as a non-invasive biomarker in HCC, showing that circulating GPC3 levels are associated with tumor expression but more closely linked to clinical outcomes, serving as an independent predictor of survival and treatment response in patients treated with atezolizumab plus bevacizumab. These findings suggest that plasma-based assessment may complement tissue-based evaluation and support real-time risk stratification in advanced HCC, although further validation in diverse, prospective cohorts is warranted.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.