ReviewFrontiers in plant science2026
Synthetic promoter design in plants: integration of computational and experimental approaches.
Review in Frontiers in plant science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Synthetic transcriptional repression systems in plants.Plant cell reports · 2026Review
- Fruit-Specific Promoters in Plants: Advances, Regulatory Mechanisms and Applications in Plant Biotechnology.Plants (Basel, Switzerland) · 2026Review
- AI-Augmented Multi-Omics for Abiotic Stress Responses: A New Frontier in Plant Hormone Systems Biology.Plants (Basel, Switzerland) · 2026Review
- Engineering Plant-Associated Microorganisms for Bioremediation and Sustainable Agriculture.Microorganisms · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Understanding how to engineer transcriptional regulation in plants is key to advancing both fundamental knowledge and practical applications in plant biology. Native gene promoters, while widely used, are constrained by evolutionary pressures that limit their modularity, tunability, and predictability across genetic backgrounds and species. Synthetic promoters, artificial DNA sequences composed of defined cis-regulatory elements (CREs) for recruitment of gene-specific transcription factors (TFs) and general transcriptional machinery, provide a powerful alternative for achieving fine-tuned transcriptional control. This review examines the design and application of synthetic promoters in plants, emphasizing current strategies, ongoing challenges, and avenues for innovation. We cover the structure of plant promoter architecture, including the contributions of core, proximal, and distal regions, and highlight how promoter grammar (i.e., motif identity, motif distance from transcription start site, spacing between motifs, helical phase of TF binding, motif orientation, and combinatorial interactions between motifs) impacts transcriptional activity. We outline how synthetic promoters are designed and validated via high-throughput reporter assays. Applications of synthetic promoters are discussed across functional genomics studies, biosensor creation, logic gate-based genetic circuits, and practical crop engineering, with examples covering constitutively expressing, hormone-responsive, pathogen-inducible, and abiotic stress-responsive promoter designs. We discuss traditional and emerging computational frameworks that enable CRE identification, novel synthetic promoter generation, and prediction of promoter sequence activity
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.