ArticleBiomedical optics express2025
Wavefront estimation through structured detection in laser scanning microscopy.
Article in Biomedical optics express, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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8 authors.
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Abstract
Laser scanning microscopy (LSM) is the base of numerous advanced imaging techniques, including confocal laser scanning microscopy (CLSM), a widely used tool in life sciences research. However, its effective resolution is often compromised by optical aberrations, a common challenge in all optical systems. While adaptive optics (AO) can correct these aberrations, current methods face significant limitations: aberration estimation, which is central to any AO approach, typically requires specialized hardware or prolonged sample exposure, rendering these methods sample-invasive, and less user-friendly. In this study, we propose a simple and efficient AO strategy for CLSM systems equipped with a detector array - image-scanning microscopy - and an AO element for beam shaping. We demonstrate, for the first time, that datasets acquired with a detector array inherently encode aberration information. As a proof-of-concept of this important property, we designed a custom convolutional neural network capable of decoding aberrations up to the 11
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