Evidence map›Paper›PMID 41767923›Full record

ArticleBiomedical optics express2025

Non-ergodicity and noise-corrected diffuse speckle contrast analysis in deep tissue blood flow measurement.

Jiachi Hong, Wenting Zhu, Bowen Zhao, Pengcheng Li, Jinling Lu

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Article in Biomedical optics express, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Jiachi HongBritton Chance Center and MoE Key Laboratory for Biomedical Photonics, Advanced Biomedical Imaging Facility, Wuhan National Laboratory for Optoelectronics-Huazhong University of Science and Technology, Wuhan, Hubei 430074, China.ORCID https://orcid.org/0000-0003-4862-2928
Wenting ZhuBritton Chance Center and MoE Key Laboratory for Biomedical Photonics, Advanced Biomedical Imaging Facility, Wuhan National Laboratory for Optoelectronics-Huazhong University of Science and Technology, Wuhan, Hubei 430074, China.
Bowen ZhaoBritton Chance Center and MoE Key Laboratory for Biomedical Photonics, Advanced Biomedical Imaging Facility, Wuhan National Laboratory for Optoelectronics-Huazhong University of Science and Technology, Wuhan, Hubei 430074, China.
Pengcheng LiBritton Chance Center and MoE Key Laboratory for Biomedical Photonics, Advanced Biomedical Imaging Facility, Wuhan National Laboratory for Optoelectronics-Huazhong University of Science and Technology, Wuhan, Hubei 430074, China.ORCID https://orcid.org/0000-0002-5695-9304
Jinling LuBritton Chance Center and MoE Key Laboratory for Biomedical Photonics, Advanced Biomedical Imaging Facility, Wuhan National Laboratory for Optoelectronics-Huazhong University of Science and Technology, Wuhan, Hubei 430074, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diffuse speckle contrast analysis (DSCA) is a valuable technique for monitoring blood flow speed, but its accuracy and sensitivity are often compromised by system noise and non-ergodicity, particularly in deep tissue measurements. Noise and static scattering tissues lead to overestimated speckle contrast and consequent underestimation of blood flow speed, especially in regions of rapid flow. To address these challenges, we developed a noise correction method integrated with a non-ergodicity calibrated model to enhance the sensitivity and accuracy of DSCA. A guide for selecting an appropriate core diameter and numerical aperture was provided for multi-mode fiber DSCA. Validation through phantom and in vivo experiments demonstrated that the non-ergodicity and noise-corrected DSCA improved the sensitivity of blood flow speed measurements in deep tissues.

Identifiers

PMID41767923
PMCPMC12945533

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