Evidence map›Paper›PMID 41767888›Full record

ArticleThe Lancet regional health. Europe2026

Community-acquired bacterial meningitis in adults in Denmark (2015-2023): a prospective, nationwide, population-based cohort study.

Henrik Nielsen, Merete Storgaard, Lykke Larsen, Birgitte Rønde Hansen, Helene Mens, Pelle Trier Petersen, Malte Mose Tetens, Christian Østergaard Andersen, Micha Phill Grønholm Jepsen, Hans Rudolf Lüttichau and 3 more

Abstract read
In one paragraph

Article in The Lancet regional health. Europe, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Henrik NielsenDepartment of Infectious Diseases, Aalborg University Hospital, 9000, Aalborg, Denmark.
Merete StorgaardDepartment of Infectious Diseases, Aarhus University Hospital, 8200, Aarhus N, Denmark.
Lykke LarsenDepartment of Infectious Diseases, Odense University Hospital, 5000, Odense, Denmark.
Birgitte Rønde HansenDepartment of Infectious Diseases, Hvidovre University Hospital, 2650, Hvidovre, Denmark.
Helene MensDepartment of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, 2100, Copenhagen, Denmark.
Pelle Trier PetersenDepartment of Pulmonary- and Infectious Diseases, Nordsjællands Hospital, 3400, Hillerød, Denmark.
Malte Mose TetensDepartment of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, 2100, Copenhagen, Denmark.
Christian Østergaard AndersenESCMID Study Group of Infections in the Brain (ESGIB), European Society of Clinical Microbiology and Infectious Diseases, Basel, Switzerland.
Micha Phill Grønholm JepsenDepartment of Pulmonary- and Infectious Diseases, Nordsjællands Hospital, 3400, Hillerød, Denmark.
Hans Rudolf LüttichauDepartment of Infectious Diseases, Herlev University Hospital, 2730, Herlev, Denmark.
Lothar WieseDepartment of Infectious Diseases, Sjælland University Hospital, 4000, Roskilde, Denmark.
Christian Thomas BrandtDepartment of Infectious Diseases, Sjælland University Hospital, 4000, Roskilde, Denmark.
Jacob BodilsenDepartment of Infectious Diseases, Aalborg University Hospital, 9000, Aalborg, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Data on clinical presentation and care pathways of community-acquired bacterial meningitis (CABM) remain scarce, especially in relation to whether and how pathogens are detected. This study aimed to examine clinical phenotypes of CABM. Methods: Nationwide, prospective, population-based cohort study of all adults diagnosed with CABM in Denmark from 2015 to 2023. Patients were hierarchically categorised as: 1) Positive cerebrospinal fluid (CSF) cultures, 2) Positive CSF polymerase chain reaction (PCR) tests or microscopy, 3) Positive blood cultures and CSF pleocytosis, 4) Other microbiological tests and CSF pleocytosis, and 5) Unknown pathogen and CSF pleocytosis. Findings: Among 1192 CABM episodes in 1174 adults (median age 65 years [interquartile range 52-75]; 597/1192 [50%] females), main pathogens were Interpretation: Distinct clinical phenotypes were associated with differences in pathogen distributions, timely diagnosis, treatment, and outcome. This knowledge is crucial for improvements in healthcare pathways and analyses of guideline adherence. Funding: Jacob Bodilsen was supported by the Danish Independent Research Foundation (10.46540/5243-00013B).

Indexed as

AetiologyBacterial meningitisClinical presentationDiagnosisEpidemiologyOutcomePrognosisTreatment

Identifiers

PMID41767888
PMCPMC12938858

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.