ArticleFrontiers in aging neuroscience2026
Prediction of treatment responsiveness to home-based transcranial photobiomodulation (tPBM) intervention for cognitive decline using fNIRS concurrently recorded during tPBM.
Article in Frontiers in aging neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Transcranial Photobiomodulation (tPBM) has attracted growing interest as an intervention to mitigate cognitive decline in older adults. However, some individuals do not respond to tPBM. This study explored the feasibility of predicting treatment responsiveness using functional near-infrared spectroscopy (fNIRS) recorded during therapy with a device integrating tPBM and fNIRS. Methods: Twenty-nine participants with cognitive decline underwent 12-week home-based tPBM intervention with concurrent fNIRS acquisition. Notably, fNIRS data were collected using the existing tPBM light sources, without additional hardware. After termination of the intervention, patients were classified as responders or non-responders based on changes in the global cognitive score (ΔGCS), which reflects multiple cognitive domains. Fourteen participants were classified as responders and 15 as non-responders. fNIRS data from the initial 15 trials were segmented into 5 periods. Linear regression analysis was performed to evaluate the changes in graph-theoretical indices calculated from the functional connectivity analysis of fNIRS and their relationship with ΔGCS. Participants with regression values below a designated threshold were predicted as non-responders. Results: Significant negative correlations between ΔGCS and the changes in graph-theoretical indices were observed in periods 3-5. Participants with regression values below a designated threshold were predicted as non-responders. In total, 13 participants were identified as non-responders, with 11 confirmed as non-responders after tPBM therapy. Conclusion: We explored the feasibility of applying graph-theoretical network analysis to fNIRS data for the early identification of non-responders to tPBM treatment before its completion. This novel approach can potentially enhance treatment efficacy by allowing for timely treatment planning.
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