Evidence map›Paper›PMID 41767833›Full record

ArticleFood science & nutrition2026

The Effect of Carnosine Supplementation on Depressive Symptoms and Health-Related Quality of Life in Individuals With Prediabetes and Well-Controlled Type 2 Diabetes: A Randomized Controlled Trial.

Robel Hussen Kabthymer, Jack Feehan, Aya Mousa, Giancarlo Aldini, Maximilian de Courten, James Cameron, Barbora de Courten

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Food science & nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Robel Hussen KabthymerDepartment of Medicine, School of Clinical Sciences Monash University Clayton Victoria Australia.
Jack FeehanSchool of Health and Biomedical Sciences RMIT University Bundoora Victoria Australia.
Aya MousaMonash Centre for Health Research and Implementation (MCHRI), Faculty of Medicine, Nursing and Health Sciences Monash University Clayton Victoria Australia.
Giancarlo AldiniDepartment of Pharmaceutical Sciences University of Milan Milan Italy.
Maximilian de CourtenInstitute for Health and Sport Victoria University Footscray Victoria Australia.
James CameronDepartment of Medicine, School of Clinical Sciences Monash University Clayton Victoria Australia.
Barbora de CourtenDepartment of Medicine, School of Clinical Sciences Monash University Clayton Victoria Australia.ORCID https://orcid.org/0000-0001-8760-2511

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Type 2 diabetes mellitus (T2DM) is commonly associated with mental health disorders such as depression and anxiety. Carnosine, an over-the-counter food supplement, may improve depressive symptoms through its anti-inflammatory properties; however, its effects on depressive symptoms and quality of life in prediabetes or T2DM remain unexplored. This randomized controlled trial aimed to examine whether carnosine supplementation may improve depressive symptoms and quality of life among individuals with prediabetes and well-controlled T2DM. A total of 38 participants (73.6% male) with a median (IQR) age of 54.8 years (46.2, 59.4) and mean ± SD body mass index (BMI) of 29.0 ± 4.2 kg/m

Indexed as

carnosinedepressiondiabeteshistidine containing dipeptideprediabetesquality of life

Identifiers

PMID41767833
PMCPMC12935567

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.