Evidence map›Paper›PMID 41767830›Full record

ArticleEuropean heart journal open2026

Impella preserves haemodynamics with adequate stressed blood volume and normal pulmonary vascular resistance in a goat model of ventricular fibrillation.

Shohei Yokota, Takaaki Maruhashi, Midori Kakuuchi, Takuya Nishikawa, Hiroki Matsushita, Hidetaka Morita, Kei Sato, Yuki Yoshida, Toru Kawada, Kazunori Uemura and 2 more

Abstract read
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In one paragraph

Article in European heart journal open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Shohei YokotaDepartment of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center Research Institute, 6-1 Kishibe-Shimmachi, Suita, Osaka 564-8565, Japan.
Takaaki MaruhashiDepartment of Emergency and Critical Care Medicine, Kitasato University School of Medicine, 1-15-1, Kitazato, Minami-ku, Sagamihara-shi, Kanagawa 252-0373, Japan.
Midori KakuuchiDepartment of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center Research Institute, 6-1 Kishibe-Shimmachi, Suita, Osaka 564-8565, Japan.
Takuya NishikawaDepartment of Research Promotion and Management, National Cerebral and Cardiovascular Center Research Institute, 6-1 Kishibe-Shimmachi, Suita, Osaka 564-8565, Japan.ORCID https://orcid.org/0000-0002-4951-7831
Hiroki MatsushitaDepartment of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center Research Institute, 6-1 Kishibe-Shimmachi, Suita, Osaka 564-8565, Japan.
Hidetaka MoritaDepartment of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center Research Institute, 6-1 Kishibe-Shimmachi, Suita, Osaka 564-8565, Japan.
Kei SatoDepartment of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center Research Institute, 6-1 Kishibe-Shimmachi, Suita, Osaka 564-8565, Japan.
Yuki YoshidaDepartment of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center Research Institute, 6-1 Kishibe-Shimmachi, Suita, Osaka 564-8565, Japan.
Toru KawadaDepartment of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center Research Institute, 6-1 Kishibe-Shimmachi, Suita, Osaka 564-8565, Japan.
Kazunori UemuraDepartment of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center Research Institute, 6-1 Kishibe-Shimmachi, Suita, Osaka 564-8565, Japan.
Tomohiro NishinakaDepartment of Artificial Organs, National Cerebral and Cardiovascular Center Research Institute, 6-1 Kishibe-Shimmachi, Suita, Osaka 564-8565, Japan.
Keita SakuDepartment of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center Research Institute, 6-1 Kishibe-Shimmachi, Suita, Osaka 564-8565, Japan.ORCID https://orcid.org/0000-0002-6856-9362

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aims: Ventricular fibrillation (VF) is a frequent and life-threatening complication of acute myocardial infarction. Although the Impella device provides circulatory support solely to the left ventricle (LV), emerging reports have suggested that it may partially maintain haemodynamics even during VF. This study sought to examine this phenomenon under controlled experimental conditions. Methods and results: In eight Saanen goats, we recorded right atrial pressure (RAP), left atrial pressure (LAP), arterial pressure (AP), LV pressure, pulmonary artery flow (PAF), carotid artery flow (CAF), and coronary flow (CoF). We inserted an Impella CP and induced VF using direct current. In Protocol 1, we changed the stressed blood volume (SBV) by blood withdrawal/infusion or pulmonary vascular resistance (PVR) by pulmonary microembolisation and measured the haemodynamics during VF with Impella P4 support ( Conclusion: Impella preserved systemic, cerebral, and coronary blood flow with adequate SBV and normal PVR conditions in a goat model of VF.

Indexed as

HaemodynamicsImpellaPerfusionPulmonary vascular resistanceStressed blood volumeVentricular fibrillation

Identifiers

PMID41767830
PMCPMC12940114

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.