ArticleFrontiers in pediatrics2026
Evaluation of point-of-care hemoglobin testing vs. central laboratory measurements in neonates: a prospective study in neonatal intensive care unit.
Article in Frontiers in pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Point-of-care (POC) testing for blood gas analysis is commonly used for neonates in the Neonatal Intensive Care Unit (NICU) to determine blood gases using small blood volumes. This helps reduce blood loss and speeds up treatment. However, many clinicians remain skeptical about the accuracy of POC hemoglobin results. Our study evaluated the agreement between POC testing and laboratory measurements of hemoglobin concentration in infants born at >28 weeks gestational age. Methods: This prospective cohort study analyzed 187 paired blood samples from infants born after 28 weeks of gestation admitted to the NICU between July 2023 and December 2024. Hemoglobin levels from paired blood samples were measured using two different Methods: a POC gas analyzer and a laboratory analyzer. The laboratory analyzer (Sysmex XN-9100®) requires a minimum of 500 µL of blood, while the POC analyzer (ABL90 Flex Radiometer®) only needs 65 µL. A Bland-Altman plot was utilized for statistical analysis to assess the agreement between the two methods and to identify any systematic differences. Results: Of 197 eligible patients, 187 were enrolled in the study, with a mean gestational age of 36.6 weeks (± 3.2) at birth. There was no significant difference between the results from laboratory arterial-venous samples (16.14 g/dL) and POC testing (16.04 g/dL; Conclusion: Point-of-care testing for hemoglobin analysis using arterial-venous samples may be an alternative method for quantifying hemoglobin in neonates born at a gestational age >28 weeks. However, due to notable discrepancies between capillary POC results and laboratory results, it is essential to exercise caution when interpreting hemoglobin measurements obtained from capillary POC testing.
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