ArticleBiological psychiatry global open science2026
Ketamine Improves Anhedonic Phenotypes Across Species: Translational Evidence From the Probabilistic Reward Task.
Article in Biological psychiatry global open science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Psychedelics produce enduring enhancement of reward responsiveness in male rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Probing biomarkers and clinical utility of reward learning across species using the Probabilistic Reward Task: 20 years of findings.Nature. Mental health · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors.
Funding
Abstract
Background: Ketamine is increasingly used as a therapeutic option for treatment-resistant depression (TRD) due to its rapid antidepressant properties; however, the mechanisms underlying these effects remain elusive. Preclinical evidence suggests ketamine acts on neural pathways implicated in reward processing, but translational efforts have proven challenging due to a lack of paradigms allowing for analogous assessment of depressive phenotypes across species. Methods: We investigated the effects of a single, subanesthetic dose of ketamine on reward responsiveness in individuals with TRD (0.5 mg/kg) and rats exposed to chronic stress (10 mg/kg) using functionally identical tasks. Humans completed the Probabilistic Reward Task (PRT) twice within 48 hours, either without intervention (healthy control [HC] participants, Results: Ketamine significantly increased response bias toward the more frequently rewarded stimulus in both species, resulting in levels comparable with HCs 24 hours postadministration. Exploratory analyses in humans suggested that this effect was strongest among individuals with more pronounced baseline anhedonia. Furthermore, in both species, ketamine had no effect on measures of discriminability, suggesting that ketamine selectively improved reward learning rather than overall task performance. Conclusions: Results highlight a shared behavioral mechanism through which ketamine alleviates anhedonic behaviors and offers important implications for the treatment of people with anhedonia in TRD and related psychopathologies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.