Malathion-induced hematotoxicity, hepatotoxicity, and nephrotoxicity in male chicks.

Introduction: Exposure to malathion has been linked to various toxicities that can affect nearly every organ in the human body. This study aimed to examine how malathion toxicity affects certain sero-biochemical and hematological parameters in chickens in order to determine the harmful effects on the blood, liver, and kidneys. Methods: Two experiments were conducted as part of the study design. Experiments 1 and 2 were used to determine the LD50 value and the hazardous dose in chickens, respectively. In the first experiment, 10 groups of 30 birds each were used. Over a period of 4 weeks, each group was divided into five subgroups (with six birds in each replicate), and one group served as a control. In the second experiment, six groups of birds and one control group of 10 chicks each were used (60 + 10 birds). Results: The LD Conclusion: Hepatic, renal, and hematological functions are sensitive markers of malathion toxicity. The findings of the study provide a fundamental basis for understanding the acute toxicity of malathion in chickens. This study provides useful information for regulatory monitoring and risk assessment.