ArticleGastroenterology report2026
Exploratory biomarker findings from regorafenib plus toripalimab in patients with refractory metastatic colorectal cancer (REGOTORI study).
Article in Gastroenterology report, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Regorafenib plus sintilimab as a salvage treatment for microsatellite stable metastatic colorectal cancer: a single-arm, open-label, phase II clinical trial.Nature communications · 2025Trial
- Review
- Spatially resolved C1QCCell discovery · 2025Article
- Real-World Results of Raltitrexed Combined with S-1 and Bevacizumab in Heavily Pretreated Metastatic Colorectal Cancer.Cancer management and research · 2023Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The REGOTORI study showed that some metastatic colorectal cancer (mCRC) patients benefited from programmed death 1 (PD-1) antibody toripalimab plus anti-angiogenic tyrosine-kinase inhibitor regorafenib. However, biomarkers for this combined therapy in mCRC remain unclear. To address this gap, we performed an integrated multi-omics biomarker analysis in REGOTORI. Methods: Next-generation sequencing was performed on formalin-fixed, paraffin-embedded (FFPE) tissue and paired plasma samples. Multiplex immunohistochemistry was performed to analyze the tumor microenvironment (TME) on FFPE samples. Variant allele frequency, somatic alterations, tumor mutational burden (TMB), circulating tumor DNA (ctDNA), and TME markers were jointly assessed from both FFPE and plasma samples to explore their associations with clinical outcomes under regorafenib plus toripalimab. Results: A total of 35 patients were included. Patients with lower ctDNA maximum somatic allele frequency (maxAF), high-allele-frequency blood-based TMB (HAF-bTMB), blood-based intratumor heterogeneity (bITH), or HAF-bITH had longer survival time than their respective counterparts. Somatic alterations in Conclusion: In this combination-therapy-focused multi-omics analysis integrating tissue genomics, ctDNA features/dynamics and TME profiling, we identified ctDNA maxAF, HAF-bTMB, bITH, HAF-bITH, mutational status of
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