Evidence map›Paper›PMID 41767623›Full record

ArticleKidney international reports2026

Association of Kidney Volume With Patient-Reported Outcomes in ADPKD.

Jad Fadlallah, Matthew Ho, Muhammad T Hassan, Taher Dehkharghanian, Mauricio Miranda Cam, Seung Heyck Lee, Saima Khowaja, Daniel G Bichet, Pierre A Brown, Matthew B Lanktree and 5 more

Abstract read
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In one paragraph

Article in Kidney international reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Jad FadlallahDivision of Nephrology, University Health Network and University of Toronto, Toronto, Ontario, Canada.
Matthew HoDivision of Nephrology, University Health Network and University of Toronto, Toronto, Ontario, Canada.
Muhammad T HassanDivision of Nephrology, University Health Network and University of Toronto, Toronto, Ontario, Canada.
Taher DehkharghanianDivision of Nephrology, University Health Network and University of Toronto, Toronto, Ontario, Canada.
Mauricio Miranda CamDivision of Nephrology, University Health Network and University of Toronto, Toronto, Ontario, Canada.
Seung Heyck LeeDivision of Nephrology, University Health Network and University of Toronto, Toronto, Ontario, Canada.
Saima KhowajaDivision of Nephrology, University Health Network and University of Toronto, Toronto, Ontario, Canada.
Daniel G BichetDivision of Nephrology, University of Montreal, Montreal, Quebec, Canada.
Pierre A BrownDepartment of Medicine, Division of Nephrology, University of Ottawa, Ottawa, Ontario, Canada.
Matthew B LanktreeDivision of Nephrology, McMaster University, Hamilton, Ontario, Canada.
Louise MoistDivision of Nephrology, Western University, London, Ontario, Canada.
Bill WangPatient Liaison Advisory Group of the International Society of Nephrology, Hong Kong, China.
Korosh KhaliliDepartment of Medical Imaging, University Health Network and University of Toronto, Toronto, Ontario, Canada.
Istvan MucsiDivision of Nephrology, University Health Network and University of Toronto, Toronto, Ontario, Canada.
York PeiDivision of Nephrology, University Health Network and University of Toronto, Toronto, Ontario, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Autosomal dominant polycystic kidney disease (ADPKD) may impose physical and emotional burdens, partly through enlarged kidneys. The association of health-related quality-of-life (HRQOL) with total kidney volume (TKV) remains unclear, particularly in combination with kidney function and pain status. Methods: Participants diagnosed with ADPKD were recruited between 2017 and 2023. We examined the associations of TKV, estimated glomerular filtration rate using the Chronic Kidney Disease Epidemiology Collaboration race-free creatinine equation (eGFR), and chronic kidney pain (Yes/No) with HRQOL (Short Form-36 [SF-36] scores) using multivariable linear regression. Factor analysis of mixed data (FAMD) was used to classify patients into clusters based on TKV, eGFR, and kidney pain; and their HRQOL was compared. Results: Of 456 participants, mean (SD) age was 47 (16) years, 216 (47%) were males, eGFR was 81 (27) ml/min per 1.73 m Conclusion: TKV is associated with physical health, independent of kidney pain and function, and with mental health (MH) indirectly through kidney pain. Alleviating kidney pain, preserving function, and limiting kidney enlargement in ADPKD may all help to improve HRQOL.

Indexed as

ADPKDpatient-reported outcomestotal kidney volume

Identifiers

PMID41767623
PMCPMC12936523

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.