Evidence map›Paper›PMID 41767622›Full record

ArticleKidney international reports2026

Markers of Mineral Metabolism in Children With CKD Stages 2 to 5D.

Anna Tschirner, Hannah Weber, Katharina Schermuly, Ineke Böckmann, Marko Pekic, Nele Kanzelmeyer, Jens Drube, Dieter Haffner, Maren Leifheit-Nestler

Abstract read
In one paragraph

Article in Kidney international reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Anna TschirnerDepartment of Pediatric Kidney, Liver, Metabolic and Neurological Diseases, Pediatric Research Center, Hannover Medical School, Hannover, Germany.
Hannah WeberDepartment of Pediatric Kidney, Liver, Metabolic and Neurological Diseases, Pediatric Research Center, Hannover Medical School, Hannover, Germany.
Katharina SchermulyDepartment of Pediatric Kidney, Liver, Metabolic and Neurological Diseases, Pediatric Research Center, Hannover Medical School, Hannover, Germany.
Ineke BöckmannDepartment of Pediatric Kidney, Liver, Metabolic and Neurological Diseases, Pediatric Research Center, Hannover Medical School, Hannover, Germany.
Marko PekicDepartment of Pediatric Kidney, Liver, Metabolic and Neurological Diseases, Pediatric Research Center, Hannover Medical School, Hannover, Germany.
Nele KanzelmeyerDepartment of Pediatric Kidney, Liver, Metabolic and Neurological Diseases, Pediatric Research Center, Hannover Medical School, Hannover, Germany.
Jens DrubeDepartment of Pediatric Kidney, Liver, Metabolic and Neurological Diseases, Pediatric Research Center, Hannover Medical School, Hannover, Germany.
Dieter HaffnerDepartment of Pediatric Kidney, Liver, Metabolic and Neurological Diseases, Pediatric Research Center, Hannover Medical School, Hannover, Germany.
Maren Leifheit-NestlerDepartment of Pediatric Kidney, Liver, Metabolic and Neurological Diseases, Pediatric Research Center, Hannover Medical School, Hannover, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Changes in age- and sex-related markers for chronic kidney disease (CKD)-mineral and bone disorder (MBD) (CKD-MBD) across CKD stages 2 to 5D have not yet been studied in children. Methods: In this cross-sectional study, we investigated age, and where applicable, sex-related z-scores of 10 key markers for CKD-MBD in 170 children with stages 2-5D. Results: We identified distinct CKD stage-dependent changes in CKD-MBD markers. In CKD stage 2, elevated serum sclerostin (z-score: 0.97), total fibroblast growth factor 23 (FGF23) (z-score: 0.72) and alkaline phosphatase (AP) (z-score: 0.61) concentrations were observed in association with reduced serum phosphate (z-score: -0.62) and 1,25-dihydroxy vitamin D Conclusion: Elevated sclerostin, total FGF23, and AP concentrations in combination with reduced serum phosphate and (1,25(OH)

Indexed as

childrenchronic kidney diseaseCKD-MBDFGF23Klothosclerostin

Identifiers

PMID41767622
PMCPMC12938118

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.