ReviewFrontiers in medicine2026
Cardiovascular remodeling: key mechanisms and clinical implications linking sarcopenia and heart failure.
Review in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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0 citing papers in PubMed.
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Authors and funding
3 authors.
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Abstract
Sarcopenia and heart failure (HF) are interconnected through a bidirectional relationship in which cardiovascular remodeling serves as a critical mediator. This review examines the shared pathophysiological mechanisms-such as chronic inflammation, oxidative stress, and insulin resistance-that underlie both conditions. By integrating recent clinical and experimental evidence, we emphasize the role of cardiovascular remodeling in aggravating muscle loss in sarcopenia and cardiac dysfunction in HF. Furthermore, we discuss novel therapeutic targets directed at disrupting these common pathways. This analysis offers a unified framework for understanding the mechanistic links between sarcopenia and HF, with implications for future research and clinical strategies aimed at enhancing patient outcomes.
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