ArticleFrontiers in medicine2026
Analysis of influencing factors for 5-year transfusion-related adverse events in a tertiary hospital using real-world data.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Transfusion-related adverse events (TrAEs), though relatively uncommon, significantly impact patient safety, with multifactorial mechanisms necessitating risk identification through real-world data. Objective: This study aimed to identify independent risk factors for TrAEs over a 5-year period in a tertiary hospital to inform clinical prevention strategies. Methods: A retrospective case-control study was conducted from January 2020 to December 2024, including 84 patients with documented TrAEs and 336 matched controls without reactions. Data on demographics, transfusion history, blood product attributes, vital signs, laboratory parameters, and outcomes were extracted from hospital records. Multivariate logistic regression was used to identify independent risk factors. Results: The observation group exhibited significantly higher values in age, number of prior transfusions, and prevalence of hypertension, diabetes mellitus, cardiovascular disease, and malignancy compared to the control group ( Conclusion: TrAEs are influenced by patient age, transfusion history, comorbidities, and transfusion volume. Enhanced monitoring and tailored transfusion strategies are recommended for high-risk patients to improve safety.
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