Evidence map›Paper›PMID 41767490›Full record

ArticleJAC-antimicrobial resistance2026

Laura J Rojas, Elsa De La Cadena, Steven H Marshall, Susan D Rudin, Pilar García, Norma C Serrano, Ligia Stella Meneses, María V Villegas, Robert A Bonomo

Abstract read
In one paragraph

Article in JAC-antimicrobial resistance, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. NDM-1-producingJAC-antimicrobial resistance · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Laura J RojasDepartment of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Elsa De La CadenaGrupo de Investigación en Resistencia Antimicrobiana y Epidemiologia Hospitalaria, Universidad El Bosque, Bogotá, Colombia.
Steven H MarshallLouis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, OH, USA.
Susan D RudinLouis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, OH, USA.
Pilar GarcíaCentro de Investigaciones Fundación Cardiovascular de Colombia, Floridablanca, Colombia.
Norma C SerranoHospital Internacional de Colombia, Piedecuesta, Colombia.
Ligia Stella MenesesHospital Internacional de Colombia, Piedecuesta, Colombia.
María V VillegasGrupo de Investigación en Resistencia Antimicrobiana y Epidemiologia Hospitalaria, Universidad El Bosque, Bogotá, Colombia.
Robert A BonomoDepartment of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine, Cleveland, OH, USA.ORCID https://orcid.org/0000-0002-3299-894X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Carbapenem-resistant Enterobacterales (CRE) frequently cause serious, life-threatening infections with limited treatment options. The most common mechanism of carbapenem resistance is carbapenemase production. Colombia is considered endemic for KPC, while metallo-β-lactamases such as NDM and VIM are increasingly circulating. An emerging concern is the appearance of strains harbouring more than one carbapenemase. Here, we report a sentinel Methods: Results: Multiplex PCR revealed the presence of Conclusions: Although the emergence of triple-carbapenemase producers has been reported, it remains rare. However, sentinel isolates as the one described here (KPC-VIM-NDM) are extremely worrisome since dissemination of multiple carbapenemases could occur via conjugative plasmids in addition to horizontal gene transmission via mobile genetic elements. Considering that Colombia has long been considered a KPC-endemic country, the findings described here call for a thorough epidemiological surveillance to assess the real frequency of Enterobacterales carrying multiple carbapenemases.

Identifiers

PMID41767490
PMCPMC12947580

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.