ArticleMacromolecules2025
Synthesis and Molecular Characterization of Pyrene-Containing Copolymers as Potential MALDI-TOF MS Matrices.
Article in Macromolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Due to its exceptional sensitivity, accuracy, and speed, matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry has emerged as a vital analytical tool, especially for the determination of low-molecular-weight compounds (e.g., lipids, metabolites). Continuous advancements in MALDI-TOF technology have expanded its applications. The employment of polymeric materials as matrices has proven to be effective in overcoming significant challenges (self-ionization and adduct formation), particularly those related to interfering background signals in the low-molecular-weight region, making the development of effective matrices a critical area of research. We investigated the synthesis of well-defined polymers that meet the requirements of a suitable matrix for MALDI-TOF MS. In this study, pyrene was chosen as a chromophore to enhance the optical properties of the polymers, taking advantage of its aromatic structure and prominent absorption capabilities. We present the detailed synthesis of novel linear polymers through reversible addition-fragmentation chain transfer polymerization, which afforded macromolecules in a controlled manner and with narrow dispersity (
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.