Genotype-phenotype correlations of fasting C-peptide and lipids in HNF1A-MODY: a single-center series and multi-center cross-sectional analysis in Chinese population.

Mengyu Wang, Hulian Huang, Hualin Liu, Huihui Tian, Xinguo Hou, Li Chen, Meng Tian, Lingshu Wang

Abstract readMulticenter Study

In one paragraph

Article in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mengyu WangDepartment of Endocrinology and Metabolism, Qilu Hospital of Shandong University, Jinan, Shandong, China.

Hulian HuangDepartment of Endocrinology and Metabolism, Qilu Hospital of Shandong University, Jinan, Shandong, China.

Hualin LiuDepartment of Endocrinology and Metabolism, Qilu Hospital of Shandong University, Jinan, Shandong, China.

Huihui TianJinan Aixin Zhuoer Medical Testing Co., Ltd, Jinan, Shandong, China.

Xinguo HouDepartment of Endocrinology and Metabolism, Qilu Hospital of Shandong University, Jinan, Shandong, China.

Li ChenDepartment of Endocrinology and Metabolism, Qilu Hospital of Shandong University, Jinan, Shandong, China.

Meng TianDepartment of Endocrinology, Weihai Municipal Hospital, Weihai, Shandong, China.

Lingshu WangDepartment of Endocrinology and Metabolism, Qilu Hospital of Shandong University, Jinan, Shandong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: HNF1A-MODY is one of the most prevalent subtypes of maturity-onset diabetes of the young (MODY). Individuals with HNF1A-MODY display considerable clinical heterogeneity, potentially attributable to specific mutation sites. However, in the Chinese population, the relationship between distinct mutation sites and clinical manifestations remains to be investigated. Methods: In the initial analysis, 23 HNF1A-MODY patients diagnosed at the Department of Endocrinology, Qilu Hospital were included. These patients were followed up regularly to monitor glycemic control status and the progression of complications. In the subsequent analysis, baseline information of 113 Chinese HNF1A-MODY retrieved from public databases were further enrolled. Analysis of covariance was conducted to investigate the genotype-phenotype associations. Results: This study included a total of 136 patients. Among the 23 from Qilu Hospital, 22 distinct Conclusion: This study revealed the correlation between

Indexed as

C-PeptideDiabetes Mellitus, Type 2Hepatocyte Nuclear Factor 1-alphaLipidsAdolescentAdultChildChinaCross-Sectional StudiesEast Asian PeopleFastingFemaleGenetic Association StudiesHumansMaleMiddle AgedC-PeptideHepatocyte Nuclear Factor 1-alphaHNF1A protein, humanLipidsclinical characteristicsgenotype-phenotype correlationHNF1A mutationsmaturity-onset diabetes of the youngtype 3

Identifiers

PMID41767394

DOI10.3389/fendo.2026.1735596

PMCPMC12935643

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