ArticleFrontiers in endocrinology2026
Nonlinear association of serum uric acid and C-peptide with arterial stiffness in patients with type 2 diabetes: a real-world study.
Article in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Diabetes has become one of the most serious and prevalent chronic diseases, and its cardiovascular complications are responsible for over 50% of diabetes-related deaths. However, the relationships between uric acid (UA) and C-peptide on arterial stiffness (AS) in patients with type 2 diabetes mellitus (T2DM) are still poorly understood. This study aimed to evaluate the associations between UA and C-peptide with AS in T2DM patients. Methods: In this cross-sectional study of 1,715 participants with T2DM, we recorded levels of fasting UA, C-peptide, and other characteristics. Elevated AS was defined as a brachial-ankle pulse wave velocity (baPWV) of ≥1,400 cm/s. Logistic regression and a restricted cubic spline (RCS) model were employed to assess the associations of UA and C-peptide with AS. Results: Fasting UA and C-peptide levels were independently and significantly associated with elevated AS in patients with T2DM, as determined by multivariate analyses ( Conclusion: The elevated AS odds in patients with T2DM were nonlinearly associated with the levels of serum fasting UA and C-peptide.
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