ReviewiScience2026
Effects of fatty acids and cholesterol on functions and behavior of bone marrow mesenchymal stem cells.
Review in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bone marrow (BM) mesenchymal stem cells (BM-MSCs) have a crucial role in BM homeostasis and regenerative therapy. While lipids are known to be fundamental components of metabolism, their precise role in modulating the function and behavior of BM-MSCs remains unclear. In this review, we present a comprehensive update on the biology of BM-MSCs in response to fatty acids and cholesterol, which are the major health-related lipids. We discuss the importance of BM as a receptor and producer of lipids and summarize the mechanistic insights by which cholesterol and fatty acids, including endocannabinoids and short-chain fatty acids, regulate BM-MSC stemness, rejuvenation, and commitment. Understanding the complex and interdependent role of lipids on BM-MSCs is critical for proper BM and bone homeostasis. Future research should focus on the development of metabolic strategies to optimize health of the BM and its cells and to refine treatments for BM-related diseases or tissue regeneration.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.