ArticleiScience2026
The impact of nicotine on the olfactory memory and its relationship with TRPA1.
Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- Associations between dual use of combustible cigarettes and electronic nicotine delivery systems and allergic rhinitis: An analysis of KNHANES data.The World Allergy Organization journal · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Olfactory disorders are related to cognitive decline, yet effective treatments remain limited. Cigarette smoke impairs olfaction, but one of its components, nicotine, can protect nerve cells in the central nervous system. Transient receptor potential ankyrin 1 (TRPA1) is expressed in central olfactory tract conduction and can be activated by nicotine. We therefore investigated whether nicotine influences olfaction through TRPA1. After inducing olfactory damage with methimazole, one of the following agents was then administered for 42 days to wild-type (WT) and TRPA1 knockout (TRPA1 KO) mice: phosphate-buffered saline, cigarette smoke extract, or nicotine. Olfactory behavioral testing and histological analyses were performed. In WT mice, intraoral nicotine improved olfactory memory and reduced neuronal apoptosis in the piriform cortex (PC). In TRPA1 KO mice, however, these effects of nicotine were abolished. Nicotine improved olfaction through TRPA1 in central olfactory tract conduction. Nicotine may thus represent a potential therapeutic strategy for olfactory impairment.
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